Migrating Motor Complex (MMC) and Digestive Health

Migrating Motor Complex (MMC) and Digestive Health

Your digestive system eliminates waste through a process known as the migrating motor complex. The cycle of the peristalsis of the gut occurs every two hours. The MMC (migrating motor complex) cycle includes four phases: 1

  1. The first phase is a period of intestinal smooth muscle calmness lasting 45 to 60 minutes, which only rare action potentials and contractions occur.
  2. The second phase is a period of roughly thirty minutes in which peristaltic contractions occur and progressively increase in frequency. Peristalsis originates in the stomach and propagates throughout the small intestine.
  3. The third phase lasts five to fifteen minutes and consists of rapid, evenly spaced peristaltic contractions. In contrast to the digestive period, the pylorus remains open during these peristaltic contractions, allowing many indigestible materials to pass into the small intestine.
  4. The fourth and final phase is a short period of transition between the strong contractions that occur in the third phase and the inactivity that occurs in the first phase.

During the migrating motor complex increased gastric, biliary, and pancreatic secretion occurs to help further digestion and decrease bacterial buildup in the proximal segments of the digestive tract. It is believed that the MMC is controlled by the enteric hormone motilin. Ingestion of food overrides the migrating motor complex, therefore, fasting has to occur regularly to help complete the process. The typical “growling” sounds you hear when you are hungry might be the MMC doing its job, cleaning your bowels of waste and excessive bacteria through increased peristalsis. 2 3

As much as 70% of people afflicted with SIBO (small intestinal bacterial overgrowth) experience a disruption of MMC rhythm. Excessive methane/hydrogen gasses produced by overgrowth of bacteria in the gut has been linked to decreased migrating motor complex function. When the second and third phase of the MMC is reduced, bacteria remain in the small intestine instead of being pushed back into the large intestine. Bacteria are then able to adhere and propagate in the small intestine, which increases inflammation and intestinal permeability. Inhibition of MMC homeostasis drives the vicious SIBO cycle. 4

Reduction of stomach acid by using acid reducing medications or H. pylori infection can contribute to poor migrating motor complex function. Lack of exercise, grazing, and constipation can contribute to poor migrating motor complex function. Being overstressed and anxious can also decrease MMC function. Finally, low thyroid function and adrenal fatigue can lower migrating motor complex frequency. 5

Fasting for at least four hours after meals during SIBO protocols might be beneficial in re-regulating the MMC. The increase in fasting time gives your body longer time to complete the MMC process. MMC also occurs during sleep, which proper sleep may be more helpful because of the longer total fasting time that normally occurs during sleep. Frequent exercise also helps to regulate the MMC properly. 6 7

  1. I suggest noni for sibo , has anyone tried iodine to get rid from sibo permanently?

  2. Treated my SIBO by:
    1. Fast Track Diet- cured most except not cured LPR
    2. LCHF-cured most of LPR but still remained and energy low
    3. Keto- more saturated fat in form of coconut oil seems to dampen down bacterial growth
    Bacteria have a preference for any type of carbohydrate but can digest 20% proteins, fat is the least preferred
    4. Keto Carnivore IF- eliminated all plant material and most dairy- usually 2 meals one at12:00pm and last not later than 8:00pm- no more SIBO, LPR most reduced when eat higher fat keto that includes coconut oil

    What I’ve learned- herbal antibiotics do not cure any better than standard because they cause more virulent strains to grow in small intestine birthed by the bacteria that remained. Intermittent fasting helps, fat is the safest food for SIBO. When you flare up eat higher fat and lower protein and no dairy. Eat red meat, liver and sweetbreads for nutrients but don’t be afraid to supplement B12, Mag/Pott, DHA/EPA, K2 and D3.

  3. Hi there, does taking supplements in between meals or before bed interrupt the MMC? If I eat around 7 PM and go to bed around 9 or 10 and take magnesium, MotilPro, and vitamin C is that disrupting the fast?
    I let 4 hours go by before eating each meal but sometimes take supplements inbetween as well.

    • Has there been a response to this? I’ve been wondering too.

    • Would love an answer to this as well. In particular, I’m considering taking ginger and oregano oil between meals, but only if it won’t stop the MMC.

  4. In my experience and those of others, IBEROGAST is an excellent prokinetic. I wonder what John thinks of it’s use long term.

    I think doing some reflexology (check Donna Eden) and Hatha yoga targetting the colon (Check Nauli Kriya, Ramdev yoga, youtube ) consistently might help immensely too. IN fact it might be more effective than anything that is ingested from a long term benifit perspective.

  5. What about injecting Botox into the muscle or something like that. Are there any studies on that?

  6. When you say the MMC is not functioning properly, what does that mean? What are the symptoms of a poorly functioning MMC? My stomach grumbles 45 minutes after eating. I try to ignore it but it only gets more intense. I can not go more than 2 hours without eating because I get headaches and start feeling unwell. I don’t feel like I should have the grumbling so soon after I eat. Does anyone have any suggestions? My stomach just doesn’t feel right but I’ve already been checked for an ulcer and the endoscopy showed no ulcers. I have food allergies so I follow an anti-inflammatory diet. I just can’t figure out what is causing these frequent stomach rumbling.

    • Do you have SIBO?

    • I would recommend staying away from regular medical doctors because they are clueless and can make matters worse. A holistic medical doctor or functional practitioner would be the way to go. There are also some chiropractors, acupuncturists and naturopaths who specialize in gut and autoimmune disorders. You could even work with some experts long-distance. This will be a process. There is no magic pill or magic wand. It is a lifestyle change, and what we eat plays a huge role. Food intolerances and autoimmunde disorders (and even hashimoto’s) can also be factors, as well as heavy metal toxicity, adrenals and cortisol levels. So you need someone who specializes in this stuff. The US “sick care” system won’t be able to help, because insurance companies, pharmaceutical companies and hospitals make billions keeping people sick and caught up in the system. So that’s why so many of us now take responsibility for our own health…because we can actually heal that way.

    • The MMC is what controls your gut motility. Symptoms can range from constipation, diarrhea, gastroparesis, dysbiosis, SIBO (malfunctioning illeocecal valve), and bloating from excessive fermentation. It would appear that you are dealing with blood glucose regulation issues if you are hungry that close after a meal.

  7. So basically what can one do to get the bowels going if it has been 5 days now and nothing happening.
    It just seems to be getting worse.

    • Go see a naturopath.

    • Fast. Stop eating g for a couple days and your MMC will kick in.

      • I didn’t eat anything for 3 days, then in the 2 weeks that followed, ate one small meal, then fasted on liquids (green juice and bone broth) the other 23 hours of the day. All of that, and nothing. Hasn’t seemed to have helped at all. Any thoughts?

  8. Really great text! Thank you for these important thoughts on handling SIBO!
    I’ve been struggling with digestion issues for a couple of years now and was diagnosed with SIBO just a few months ago. Overall I’ve lost more than 20 pounds throughout the years/months and now trying to get a long with a serious underweight.
    One of my major problems is, that my symptoms are really bad after eating normal servings of all kinds of food (or even after what an ordinary eater would name a small serving). So I started eating quite tiny quantities every hour. Anyway I definitely agree on your thoughts on the MMC cycle, cos I feel so much better after some hours of not eating (although I’m hungry and at some point out of energy).
    But I really don’t know how to get started with those four hours of fasting between the meals or just eating three/four times a day. Cos from my perspective this meals would need to be so huge!
    So do you have any further advice how to eat quite small quantities but considering the MMC cycle?

    And again: thank you for your explanations on SIBO and MMC. They really helped me understanding some important essentials.

    • I don’t know if you’re still dealing with this – but I had the same problem! It only took me about 1 week to go from small meals 3x a day (which sucked) and work up to larger meals that I could tolerate. IBGuard and Atrantil are two products that helped me with the bloating and gastritis symptoms so I could have bigger meals. Diet change too, but that was harder bc it seemed like it was everything…good luck!

  9. thanks, good write up. Ive had SIBO for five years now, IBS for 10 years prior (it was probably just SIBO but less worse then). I just started erythomycin prokinetic last night. I had to throw a fit at kaiser so my specialist would give it to me. She wont continue it for more than three months, even if it works great. Ive done every test. It has to be the MMCs. For one, i dont ever hear my stomach growl. I get recurrent SIBo that doesnt respond to rifaximin anymore, only this drug with flagyl. But im done with antibiotics and have been starving myself basically. I eat six-seven hours apart, 3 times a day. Its tough but keeps the worst symptoms at bay (rotten egg burps, bloating, diahrea, smelly gas, nausea, etc). Do what you can to get a prokinetic, fight for it. And space your meals out

    • See if you can get a doctor to order IBScheck! It will definitively show that you need help with your MMC. Google that test name and there is good info on their site. I was positive so my doctor believes me that my MMC is messed up!

      • Can you tell me if you’ve fully recovered? I have the antibodies also after food poisoning but don’t want to be on a prokentic forever!

  10. I was diagnosed with hydrogen dominant SIBO two months ago after suffering for years with varied “mystery” symptoms. I took a round of Rifaxamin and felt so much worse. Then, tried Candibactin for six weeks. I’ve been very depressed and anxious. I am now trying Low Dose Naltrexone which I got from a clinic in Scotland. I have not seen a gastrointerologist but am anxious to do so. I’m wondering if you believe a fecal microbiota transplant will help. I’m two days off sugar. I have been a junkie but am now too sick to go on like that.

    • Do not see the gastroenterologist! Mostly they refuse to acknowledge bad gut bacteria! They tell u it’s IBS and treat the symptoms! Never treating the root cause, which makes IBS incurable! U have to cut out the sugar! You have to! Got to parasitetesting.com and order the FCR freedom cleanse restore. It has ALL the herbal remedies in three different supplements for three different purposes! Freedom fights the bad guys. Restore helps restore digestive tract damage. Cleanse helps clear out the stuff u have killed with the other two. This plus the right diet, which is not easy! I’m working on it now and seeing some improvements but it is a long road and the die off often feels like the issues from having the overgrowth in the first place, but u will see little signs along the way! Candida diet with a few small adjustments becomes the SIBO diet

  11. John, how do you know if the MMC is messed up? By bowel regularity? Is there a test? Likewise, how do you know when its normalized?

    • There is a test called IBScheck that will tell you for sure if your MMC is disturbed. It doesn’t rule it out though! But if positive, you definitely have an issue.

  12. It is not a good idea to make upset the MMC, ruining the metabolic rhythm of yours, fasting 4 hours maybe is a tolerable habit but not 6 hours. It is good to stimulate the MMC with good habits, as for example visiting alien places, holy churches, because that can boost MMC due to fear reactions.

  13. Does anyone know if exercising right after eating increases the function of the MMC? I know exercise in general does, but I’m thinking a short and easy walk after each meal might encourage it further. Any thoughts?

    • It should in theory increase the MMC from increased adrenaline, blood pressure, and heart rate. Some people would say that it would pull blood from the digestive organs which may slow it down. All you can do is try and see!

  14. Many thanks for this great information,

    I have been taking Omeprazol for 3 years, and I dont know if it is the reason for my reduced MMC and if it is the causing to not cure from SIBO.
    I was trying some natural herbal antibiotics like chili pepper and ginger, whcih I found very helpful, but it does not cure it for good.
    1- Do you think reducing my meals size and having 5 meals aday is good for me?
    2- Is there any safer replacements for omeprazol, because I tried to quit of it, but this cause a hearburn for me?
    3- how not to loose weight in this fasting system ?

    With my best regards

    • 1. No that would slow down MMC function. It is best to eat three meals daily and chew the food very, very well to prevent poor digestion and overeating.
      2. It is normal for that to occur, it is called rebound reflux. I recommend working with your doctor to titrate the dose slowly on the PPI. Taking d-limonene and zinc carnosine may help with that. I would also get your B12 levels checked and supplement with magnesium to help with PPI caused deficiencies.
      3. Continue working on reducing overgrowth and hopefully absorption of nutrients will normalize and your weight will stabilize.

    • I recommend FCR FREEDOM CLEANSE RESTORE FROM parasitetesting.com or PCI wellness , WHICH IS THE SAME COMPANY. That plus diatomaceous earth plus the right diet! I’m only 3 months in to this treatment but am seeing results, small things you will notice bc you are very aware of all the little things your body has already been doing , so thru the pain and burping and etc, u will know it’s the stuff working and not the SIBO eating, since much of the die off seems the same as the issue itself! It gets confusing but u will start to see enuf to see its working

  15. Hello,

    I’m curious what actually interrupts the MMC. My natural doc has me taking supplements mid-morning, and I also sip on coffee or tea as well as water. What about other drinks? Bone broth for instance? I’m pretty sure poor MMC is the reason I developed SIBO, and really want to get rid of it and not get another occurrence. I’m up for “fasting” for 3-5 hours between meals, but I can’t find information on what that means.

    Thanks for the great info!

    • It is uncertain if liquids interrupt the MMC. It is unlikely that if it does it would last very long. Bone broth might interrupt it for a little longer because it contains protein that needs to be digested. I would only trust water and maybe tea or coffee.

    • My doctor told me anything with calories will disrupt/restart the whole process.

  16. if sibo, check for an announcement from Dr Mark Pimentel coming in May.

    If your diet is not absolute complete perfection, then you are throwing your money away on everything else. You cannot ingest a morsel of refined sugar or processed food in the day, and likely dairy too. Eat a low fodmap diet. No point to go too low carb since the bugs will merely go into “survival” mode.

    All else fails, the elemental diet and a prokinetic.

  17. Hi thanks for sharing all the great info on your site!

    I have been battling (sort-of) SIBO for about 2 years now – confirmed by the hydrogen breath test done at Straub Hospital Honolulu. I too believe I’ve had it for many years but it only became seriously problematic a year or so after a week of double IV administered heavy-duty dose antibiotics for a blood infection which hospitalized me (for 7 days!) followed by an intense bout of nasty nasty food poisoning less than a year later… Talk about THE perfect storm!

    This past march I did 10 days of Xifanan (Rifaximin) but did not change much regarding diet. The SIBO symptoms came back oh just a few months later – mine are;

    TONS of hydrogen gas high in my stomach often impossible to burp up and of course much increased muscle & joint pain, MORE tinnitus and now, I have minor “throbbies” with tingly extremities, burning feet, super light headed when getting up rapidly, and for the past few years my hair has been falling out – MORE these past 7 months. :-( and constantly fighting mild depression.

    I did not know all the ins & outs regarding lipopolysaccharides aka LPS and its relation to my chronic joint and muscle pains, the tough protective biofilms, the possible low thyroid connection, the controversy of a higher fat diet being not so optimal (shucks I was happy & excited about doing a modified paleo – (no sweet potatoes!) .

    I just ordered InterPhase and yesterday started on Wobenzyme proteolytic enzymes (for all that nasty inflammation I am sooooooo tired of!!) and now am purchasing the Lactoferrin too.

    I have good herbal antimicrobials Dysbiocide & FC Cidal* (Biotics Research Laboratories) and very good probiotics but will stop taking all these until after I have been on the Interphase, Lactoferrin and proteolytic enzymes for a few days.

    My plan is to:

    1. Follow Dr. Robillards Fast Track digestion Fermentation Potential (FP) diet (don’t eat things that will ferment IN MY GUT & help bacteria multiply).

    2. Dr. Mercolas Wholefood vitamins plus minerals on my “eating” days along with extra iodine & Iron supplements, lots of digestive enzymes, Betaine HCl with my food and of course methylcobalamin form of B12. Sip on homemade kombucha (brewing now!) and eat fermented foods ie; sauerkraut, Kim chee etc.

    3. Take the systemic enzymes-empty stomach… InterPhase, Wbenzyme and Lactoferrin

    4. Do intermittent 1-2 day bone broth fasting. (I made a huge batch of 24 hour beef bone broth steeped with ginger, turmeric, onion, carrot, celery, garlic and shitake.)

    5. Probiotic supplementation


    1. DO YOU KNOW if its best to take the probiotics at night after the day of the biofilm cracking & bacteria killing OR visa versa? OR…

    2. 1-2 days of killing & fasting followed with 1-2 DAYS of eating & probiotics?

    3. Should I take the nutritional supplements even on broth fasting days? And do you think my brand choices are good?

    I am now officially afraid yet rather pissed off at these tiny bugs gassing away in my gut and even did a rare thing for a strong Dragon Aires… I cried on my husbands shoulder! I HATE feeling weak and compromised. Time to kick some ASS!

    • 1. I do not recommend taking probiotics at all during an elimination protocol unless you are hospitalized to protect from C. diff. Instead: https://fixyourgut.com/recommended-prebiotic/
      2. Possibly, but the days of water fasting might make your gut barrier worse off in the long run since glucose is required to synthesize NAG.
      3. Yes and Yes.

      Good luck!

    • The onion and garlic while good for Candida , probably will make u worse while treating SIBO and leaky gut

    • Hi Shelly,

      I’m curious how things are going for you these days? Have you gotten the SIBO under control. I too live in Honolulu area and was recently diagnoised with SIBO. That’s awesome that Straub did it, I didn’t realize conventional doctors were testing for it. For me, It’s gotten so bad that I can’t eat anything without severe pain and bloating. I’m down to 99 lbs at 5’3″ as I’m trying to wean my 9 month old from breastfeeding😥 I feel I have no choice if I want to survive. I’m starting the liquid Elemental Diet in 2 days to starve the bacteria, praying I can’t stomach it and start to gain weight and nutrients. I’m just a little lost with how to keep it under control once I’m off the diet and would love to hear what worked for you and what didn’t, that is If you wouldn’t mind sharing your experience with me. Thank you so much in advance.

      Love and Aloha,

      • Hi Holly! I know your post was directed at Shelly, but I thought I might be able to help? I’m trying to avoid getting to where you are right now!! I think it is very important you take a prokinetic as soon as you’re done with elemental, take it easy going back on Foods, and make sure that you space meals 4-5 hours apart. I know it’s a lot but that will help get your gut moving how it should so you can keep the bacteria from migrating back into your small intestines. Products that have helped me: IBguard, Atrantil, EnteraGam to heal my gut, and I’m taking LDN for prokinetic + autoimmunity issues. I also am taking Iberogast and MotilPro which you can order on Amazon as herbal Prokinetics. My doc also has me on SunFiber to help with gas, bloating, stool consistency, and colon health.

        Good luck!!!!

        • Kenrah,

          Did you have sibo c or sibo d?

          Did you have sleep issues with LDN?

          It seems like you really hit the prokinetics hard!

        • Hi Kendrah,

          I really appreciate all of your posts and sharing of information. My son has SIBO which was diagnosed in April of 2017 – however, he’s been sick for almost a year and out of school for about 7 months. It has been really hard. He did 2 rounds of Rifaximin and is currently on LDE, along with a methylation supplement. When do you take the Iberogast? Do you space eating around it? I did not realize it was a prokinetic.

      • Hi Holly,

        This is pretty late so I don’t know if you’ll see this, but how did the elemental diet go for you?? I’m in Honolulu ad well and diagnosed with SIBO in April. 2 rounds of rifaximin, 1 with metronidazole, and a round of FC Cidal & Dysbiocide and no improvement yet.. looking at the elemental diet next but I’m also struggling with weight loss issues . . .

    • I have been taking Dysbiocide and FC-Cidal for about 3 weeks and have noticed zero difference with IBS. I eat a whole food plant based diet and try to minimize high-FODMAP food. I am underweight, so I eat a lot and often, but now I wonder whether that is exacerbating my gut issues because they only rest when I sleep. I am just wondering whether the Dysbiocide/FC-Cidal regime helped you? I have been wondering if I should try water fasting for 3-5 days while taking it to give my gut bacteria populations time to decrease so the herbs might have a chance to be effective??? But I’m only 110 lbs as it is, 5’7″ and female…I am afraid to lose more weight (and afraid I might go crazy if I don’t eat every couple of hours).

    • Onion, mushrooms, and garlic are high FODMAP foods. You might want to take them out of your broth recipe.

Leave a Reply

This site uses Akismet to reduce spam. Learn how your comment data is processed.