FYG Recommends GliadinX For the Gluten Intolerant and Celiacs

Individuals with celiac disease are deeply concerned about the consequences of ingesting even trace amounts of gluten. Some symptoms of ingesting even micro amounts of gluten include joint pain, skin rashes, migraines, brain fog, cramps, bloating, and diarrhea. Gluten-degrading enzymatic supplements including GliadinX are now available to address the issue of hidden gluten within our food. While these supplements do not cure celiac disease, they may help digest small, accidental amounts of gluten before they can cause harm. 

How GliadinX Breaks Down Gluten

Tolerase G, marketed by DSM FIR Menich, is the only enzyme preparation officially approved in the European Union for digesting residual gluten. Tolerase G contains a proline-specific endopeptidase (AN-PEP) derived from the fungus Aspergillus niger. Tolerase G functions within our stomach’s acidic environment, degrading proline-rich gluten peptides into smaller, potentially harmless fragments. Emerging research suggests that they can significantly reduce or eliminate the gluten load entering our small intestine due to accidental ingestion, particularly from cross-contamination, thereby reducing immune reactions and symptoms associated with celiac disease.^{1 2 3} 

In humans, Tolerase G remains active in gastric pH conditions, resists breakdown by pepsin, and has been shown to degrade up to one gram of hidden gluten per meal when taken at a dosage of 160,000 PPI (Proline Protease Picomole International units) of prolyl-specific endopeptidase. GliadinX , my recommended Celiac disease supplement to prevent illness from cross contamination, contains Tolerase G. One capsule of GliadinX contains 194,000 PPI of Tolerase G prolyl-specific endopeptidase. If you anticipate a higher risk of cross-contamination in your meal, you can take up to five capsules per meal. For many people with celiac disease, dining out, taking one to two capsules before a potentially risky meal has become a reliable safety measure.^{4 5 6} 

The mechanism of action for AN-PEP is quite simple: it cleaves gluten peptides at proline residues, which human peptidases cannot process. In vitro studies and measurements of gastric and duodenal fluids in healthy volunteers showed that high doses (160,000 PPI) and moderate doses (80,000 PPI) of AN-PEP reduce gluten concentrations by more than ninety percent within three hours compared to a placebo. This rapid breakdown occurs in the stomach’s acidic environment before these peptides can trigger immune reactions in the small intestine. Importantly, the European Food Safety Authority (EFSA) has evaluated Tolerase G as a Novel Food and determined that daily intakes of up to 2.7 grams of the enzyme (approximately three capsules per day) are safe for adult use. No adverse effects were noted in ninety-day rat studies with doses of up to 5,180 mg/kg body weight. ^{7 8 9 10}  

Has Any Research Been Done on Tolerase-G’s Effectiveness in Preventing Celiac Disease Symptoms From Gluten Ingestion?

Research on AN-PEP containing supplements and their usefulness for people with celiac disease continues to grow. A study published in 2017 in Alimentary Pharmacology & Therapeutics confirmed that AN-PEP is effective even under harsh gastric conditions that deactivate other enzymes, highlighting its unique suitability for use in the stomach. While no enzyme can “cure” celiac disease, since there is no established safe gluten threshold for individuals with celiac disease, these proline-specific endopeptidases supplements provide a practical layer of protection against cross-contamination for those trying to adhere to a gluten-free diet in real-world situations. When dining out, asking your server about cross-contamination risks is essential. Shared fryers, flour dust in the kitchen air, and shared utensils can all introduce five to twenty-five ppm of gluten into meals that are supposed to be gluten-free. Taking a single capsule of GliadinX just before your first bite can help digest most of that residual gluten, ensuring that fewer than twenty parts per million reaches our small intestine, keeping you below the FDA’s gluten-free labeling threshold. In a Metagenics Institute supplement company published research review, individuals with celiac disease have safely enjoyed cross-contaminated pizza crusts and restaurant salad dressings when they used AN-PEP, experiencing significantly fewer symptoms compared to those who received a placebo.^{11 12} 

In a paper published in the scientific journal Nutrients, Dr. Stefano Guandalini from the University of Chicago noted that one dose of GliadinX can detoxify approximately 0.2 grams of gluten, about one-eighth of a slice of bread. GliadinX is an ideal supplement for accidental gluten exposures but should not be considered a substitute for a gluten-free diet. Many users report taking one capsule before a meal and keeping additional capsules on hand to take up to four or five doses if they suspect they have consumed more gluten than expected.^{13 14} 

GliadinX Side Effects and Recommendations

As mentioned in Amazon reviews, GliadinX has several anecdotal side effects. Some users have reported experiencing abdominal pain, gastritis, nausea, vomiting, heartburn, and diarrhea. It’s unclear whether these individuals are having negative reactions to the supplement itself or if they are experiencing physical responses to gluten, even though the enzyme has degraded it. In a few reviews, allergic reactions were also noted.   

Those with sensitivities to yeast, histamine intolerance, or mast cell activation disorder should use GliadinX with caution or consider avoiding it altogether, as it is derived from the fungus Aspergillus niger.¹⁵ 

I have used GliadinX for many years, and so far, it is the only supplement that has helped prevent my celiac disease symptoms, such as ocular migraines, intestinal itching, brain fog, diarrhea, and anxiety, particularly when I might have accidentally ingested gluten. My instances of celiac disease symptoms due to cross-contamination have significantly decreased over the years since I started taking GliadinX. I usually take one to two capsules per meal when eating out. I highly recommend this supplement to many of my family, friends, and clients, and they have seen great success as well. While GliadinX is not a cure for celiac disease and it does not grant you a license to eat gluten deliberately, it may provide extra comfort for those with the condition who risk becoming ill from accidentally eating gluten-cross-contaminated food.

Purchase GliadinX here.  

Protip: If you have celiac disease, combine supplementing with Pure Encapsulations PepticCare zinc carnosine and GliadinX when eating out to hopefully further prevent issues when you accidentally ingest cross-contaminated food.